T\u0259dqiqat\u00e7\u0131lar ya\u015fa ba\u011fl\u0131 x\u0259st\u0259likl\u0259rin m\u00fcalic\u0259si \u00fc\u00e7\u00fcn yeni yollar a\u00e7a bil\u0259c\u0259k z\u00fclal a\u015fkar edibl\u0259r.<\/p>\n
Z\u00fclal z\u0259d\u0259l\u0259nmi\u015f orqanoidl\u0259ri, h\u00fcceyr\u0259nin i\u00e7\u0259risind\u0259 vacib i\u015fl\u0259ri yerin\u0259 yetir\u0259n v\u0259 onun f\u0259aliyy\u0259ti \u00fc\u00e7\u00fcn h\u0259yati \u0259h\u0259miyy\u0259t k\u0259sb ed\u0259n alt b\u00f6lm\u0259l\u0259ri t\u0259mizl\u0259m\u0259y\u0259 k\u00f6m\u0259k edir.<\/p>\n
Onlardan ikisi – mitoxondriya v\u0259 lizosomlar m\u00fcvafiq olaraq h\u00fcceyr\u0259l\u0259rd\u0259 enerji istehsal etm\u0259y\u0259 v\u0259 onlar\u0131 sa\u011flam saxlama\u011fa k\u00f6m\u0259k edir.<\/p>\n
Bu orqanoidl\u0259rin z\u0259d\u0259l\u0259nm\u0259si ya\u015flanma v\u0259 Parkinson, Alzheimer, Huntinqton x\u0259st\u0259liyi v\u0259 amiotrofik skleroz kimi neyrodegenerativ x\u0259st\u0259likl\u0259r d\u0259 daxil olmaqla bir \u00e7ox x\u0259st\u0259likl\u0259rl\u0259 \u0259laq\u0259l\u0259ndirilir.<\/p>\n
\u201cProceedings of the National Academy of Sciences\u201d jurnal\u0131nda d\u0259rc olunan yeni ara\u015fd\u0131rmada Yaponiyan\u0131n Osaka Universitetinin v\u0259 dig\u0259r tibb fak\u00fclt\u0259l\u0259rinin aliml\u0259ri heksokinaz domeni adl\u0131 z\u00fclal\u0131n h\u0259m mitoxondril\u0259ri, h\u0259m d\u0259 lizosomlar\u0131 qoruma\u011fa k\u00f6m\u0259k etdiyini bildiribl\u0259r.<\/p>\n
Nara Tibb Universitetinin biokimya professoru, ba\u015f m\u00fc\u0259llif \u015euhei Nakamura \u201cEuronews Next\u201d\u0259 bildirib ki, “HKDC1\u201d funksiyas\u0131n\u0131n modulyasiyas\u0131 qocalma v\u0259 ya\u015fa ba\u011fl\u0131 x\u0259st\u0259likl\u0259rl\u0259 \u0259laq\u0259li h\u00fcceyr\u0259 qocalmas\u0131n\u0131n qar\u015f\u0131s\u0131n\u0131 ala bil\u0259r.<\/p>\n
H\u00fcceyr\u0259 qocalmas\u0131 h\u00fcceyr\u0259l\u0259rin b\u00f6l\u00fcnm\u0259sinin dayanmas\u0131d\u0131r ki, bu da h\u00fcceyr\u0259l\u0259rin x\u0259r\u00e7\u0259ng\u0259 \u00e7evrilm\u0259sinin qar\u015f\u0131s\u0131n\u0131 ala bil\u0259r, lakin qocalma\u011fa k\u00f6m\u0259k edir. T\u0259dqiqat\u00e7\u0131lar bildiribl\u0259r ki, b\u0259zi t\u0259dqiqatlar qocalman\u0131n qar\u015f\u0131s\u0131n\u0131n al\u0131nmas\u0131n\u0131n insan\u0131n qocalmas\u0131 v\u0259 ya\u015fa ba\u011fl\u0131 x\u0259st\u0259likl\u0259rin qar\u015f\u0131s\u0131n\u0131 ala bil\u0259c\u0259yini g\u00f6st\u0259rir.<\/p>\n
T\u0259dqiqat h\u0259m\u00e7inin HKDC1-nin a\u011fciy\u0259r v\u0259 qaraciy\u0259r x\u0259r\u00e7\u0259ngin\u0259 t\u0259sir g\u00f6st\u0259r\u0259 bil\u0259c\u0259yini x\u00fcsusi qeyd edir.<\/p>\n
“H\u00fcceyr\u0259 qocalmas\u0131n\u0131n neyrodegenerativ x\u0259st\u0259likl\u0259r, \u00fcr\u0259k-damar x\u0259st\u0259likl\u0259ri, fibroz v\u0259 z\u0259iflik d\u0259 daxil olmaqla bir \u00e7ox ya\u015fa ba\u011fl\u0131 x\u0259st\u0259likl\u0259r\u0259 t\u0259siredici g\u00fcc\u00fc var”, – Nakamura bildirib.<\/p>\n
HKDC1 funksiyas\u0131 h\u00fcceyr\u0259 qocalmas\u0131n\u0131n qar\u015f\u0131s\u0131n\u0131 alaraq bu x\u0259st\u0259likl\u0259r\u0259 potensial t\u0259sir g\u00f6st\u0259rir.<\/p>\n
Bu protein orqanoidl\u0259ri nec\u0259 qoruyur?<\/strong><\/em><\/p>\n Mitoxondriya h\u00fcceyr\u0259l\u0259r \u00fc\u00e7\u00fcn enerji yarad\u0131r. O z\u0259d\u0259l\u0259n\u0259rs\u0259 h\u00fcceyr\u0259d\u0259n \u00e7\u0131xar\u0131lmal\u0131d\u0131r. Harvard t\u0259dqiqat\u00e7\u0131lar\u0131n\u0131n fikrinc\u0259, z\u0259d\u0259l\u0259nmi\u015f mitoxondriyalar y\u0131\u011f\u0131ld\u0131qda neyrodegenerativ x\u0259st\u0259likl\u0259r ba\u015f ver\u0259 bil\u0259r. Z\u0259d\u0259l\u0259nmi\u015f mitoxondriyan\u0131n \u00e7\u0131xar\u0131lmas\u0131 \u201cmitofagiya\u201d adlanan proses vasit\u0259sil\u0259 ba\u015f verir v\u0259 PINK1 v\u0259 Parkin adl\u0131 z\u00fclallardan as\u0131l\u0131d\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":" T\u0259dqiqat\u00e7\u0131lar ya\u015fa ba\u011fl\u0131 x\u0259st\u0259likl\u0259rin m\u00fcalic\u0259si \u00fc\u00e7\u00fcn yeni yollar a\u00e7a bil\u0259c\u0259k z\u00fclal a\u015fkar edibl\u0259r. Z\u00fclal z\u0259d\u0259l\u0259nmi\u015f orqanoidl\u0259ri, h\u00fcceyr\u0259nin i\u00e7\u0259risind\u0259 vacib i\u015fl\u0259ri yerin\u0259 yetir\u0259n v\u0259 onun f\u0259aliyy\u0259ti \u00fc\u00e7\u00fcn h\u0259yati \u0259h\u0259miyy\u0259t k\u0259sb ed\u0259n alt b\u00f6lm\u0259l\u0259ri t\u0259mizl\u0259m\u0259y\u0259 k\u00f6m\u0259k edir. Onlardan ikisi – mitoxondriya v\u0259 lizosomlar m\u00fcvafiq olaraq h\u00fcceyr\u0259l\u0259rd\u0259 enerji istehsal etm\u0259y\u0259 v\u0259 onlar\u0131 sa\u011flam saxlama\u011fa k\u00f6m\u0259k edir. Bu orqanoidl\u0259rin z\u0259d\u0259l\u0259nm\u0259si ya\u015flanma v\u0259 Parkinson, Alzheimer, Huntinqton x\u0259st\u0259liyi v\u0259 amiotrofik skleroz kimi neyrodegenerativ x\u0259st\u0259likl\u0259r d\u0259 daxil olmaqla bir \u00e7ox x\u0259st\u0259likl\u0259rl\u0259 \u0259laq\u0259l\u0259ndirilir. \u201cProceedings of the National Academy of Sciences\u201d jurnal\u0131nda d\u0259rc olunan yeni ara\u015fd\u0131rmada Yaponiyan\u0131n Osaka Universitetinin…<\/p>\n","protected":false},"author":2,"featured_media":706503,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"aioseo_notices":[],"gutentor_comment":0,"rttpg_featured_image_url":{"full":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105.jpg",975,540,false],"landscape":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105.jpg",975,540,false],"portraits":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105.jpg",975,540,false],"thumbnail":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105-500x280.jpg",500,280,true],"medium":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105-660x365.jpg",660,365,true],"large":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105-840x465.jpg",640,354,true],"1536x1536":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105.jpg",975,540,false],"2048x2048":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105.jpg",975,540,false],"post-thumbnail":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105-240x172.jpg",240,172,true],"advps-thumb-one":["https:\/\/arantv.az\/wp-content\/uploads\/2024\/03\/f12ee973171173116634843886110233105.jpg",975,540,false]},"rttpg_author":{"display_name":"V\u00fcsal Rafiqo\u011flu","author_link":"https:\/\/arantv.az\/?author=2"},"rttpg_comment":0,"rttpg_category":"C\u0259miyy\u0259t<\/a>","rttpg_excerpt":"T\u0259dqiqat\u00e7\u0131lar ya\u015fa ba\u011fl\u0131 x\u0259st\u0259likl\u0259rin m\u00fcalic\u0259si \u00fc\u00e7\u00fcn yeni yollar a\u00e7a bil\u0259c\u0259k z\u00fclal a\u015fkar edibl\u0259r. Z\u00fclal z\u0259d\u0259l\u0259nmi\u015f orqanoidl\u0259ri, h\u00fcceyr\u0259nin i\u00e7\u0259risind\u0259 vacib i\u015fl\u0259ri yerin\u0259 yetir\u0259n v\u0259 onun f\u0259aliyy\u0259ti \u00fc\u00e7\u00fcn h\u0259yati \u0259h\u0259miyy\u0259t k\u0259sb ed\u0259n alt b\u00f6lm\u0259l\u0259ri t\u0259mizl\u0259m\u0259y\u0259 k\u00f6m\u0259k edir. Onlardan ikisi – mitoxondriya v\u0259 lizosomlar m\u00fcvafiq olaraq h\u00fcceyr\u0259l\u0259rd\u0259 enerji istehsal etm\u0259y\u0259 v\u0259 onlar\u0131 sa\u011flam saxlama\u011fa k\u00f6m\u0259k edir. Bu orqanoidl\u0259rin…","_links":{"self":[{"href":"https:\/\/arantv.az\/index.php?rest_route=\/wp\/v2\/posts\/706502"}],"collection":[{"href":"https:\/\/arantv.az\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arantv.az\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arantv.az\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/arantv.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=706502"}],"version-history":[{"count":0,"href":"https:\/\/arantv.az\/index.php?rest_route=\/wp\/v2\/posts\/706502\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/arantv.az\/index.php?rest_route=\/wp\/v2\/media\/706503"}],"wp:attachment":[{"href":"https:\/\/arantv.az\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=706502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arantv.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=706502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arantv.az\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=706502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}